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Brunel University

Brunel University

Aristotle University of Thessaloniki


Expert Overview Session in Biomedicine

Title: Micro and Nano Flows in Medicine: the way ahead

Biomedical engineering at small scales is challenging, inspiring and of very high importance in its medical and clinical applications. It has a two-way relationship with conventional engineering. It applies conventional micro- and nano-engineering to complex organic solids, fluids and their interactions and by doing so develops enhanced methods and techniques which can then be profitably used in engineered processes and devices. Moreover, whereas existing scientific knowledge via creative design enhances the engineered world, in biomedicine organic systems require increasingly multi-scale basic understanding. That understanding may be experimental or mathematical and through it unhealthy and diseased conditions may be addressed. Often there is a biomedicine/engineering synthesis in devices such as stents.

This Expert Session seeks to address these issues in a holistic manner with speakers of International Invited status. It was inspired by the seeming plethora of new fine-scale optical measurement methods and these feature prominently. Blood flow, clotting and interaction with tissue are treated and the generic areas of modelling and bioelectronics are also addressed. A recurring theme is biomedicine’s clinical applications and concluding assessments will be made along these lines.

It will be of particular value to new entrants to the field.

*STOP PRESS: Extended session papers will form chapters in a volume in the Springer US series:

Bioanalysis: Advanced Materials, Methods and Devices
(Series Editor, Prof Tuan Vo-Dinh, Duke University, US)

The title of the volume will be:

Nano and Micro Flow Systems for Bioanalysis
(Editors: M.W.Collins & C.S.Koenig)

Session Programme:

On Monday August 22, following Plenary & Keynote Papers.
All papers 20 minutes presentation.
Each sub-session includes assessment/discussion period

Sub-Session 1


  • Mehmet Yigit & Zdravka Medarova (Harvard Medical School) Nanoparticles for image-guided molecular therapy
  • Gianni Medoro* (Silicon Biosystems, Bologna, Italy) Detection and isolation of circulating tumour cells with single-cell resolution: a successful Lab-on-a-chip device
  • Holger Perfahl (Univ Stuttgart, Germany) et al (Lee Moffitt Cancer Center, Tampa, US/ Univ Barcelona, Spain/Univs Oxford & Nottingham, UK),3D modelling of Angiogenesis and vascular tumour growth

Sub-Session 2


  • Paul Evans (Imperial College, London) Regulation of endothelial activity & vascular inflammation by shear stress
  • Vasilios A. Karagounis (Cardiac & Thoracic Surgeon, Thessaloniki, Greece) ‘Micro flows in the Cardio-Pulmonary system: surgical perspective’ **

Blood Clotting:

  • K.Hawkinsa, A.Sowedanb, P.A.Evansa, M.J.Lawrencea & P.Rhodri Williamsb (Colleges of Medicinea and Engineeringb , Swansea Univ) (Centre for Nanohealth, Swansea, UK) Rheometrical detection of incipient clots formed under physiologically relevant conditions

Sub-Session 3

Fine-scale bio-optics:

  • Sergei Chizhik, Lizaveta Drozd & Nikita Fomin (Belarus Academy of Sciences) Digital optical and scanning probe microscopy for biocells inspection and manipulation
  • Jeremy Coupland (Loughborough Univ, UK) Coherent microscopy and Optical Coherence Tomography for biomedical applications


  • Hywel Morgan (Southampton Univ, UK) High speed single cell processing and characterisation using electric fields and microfluidics

Specialist assessments:

  • Zdravka Medarova (cancer)
  • Axel Pries (Charite Univ, Berlin, Germany) (cardiovascular)
  • Vasilios A. Karagounis (surgery)
  • Guiseppe Pontrelli (National Research Council, Rome, Italy) (fine scale modeling)

* Company recommended through Cancer Research UK Laboratory

** VAK, besides his MD, holds MS (Operations Research) and MS & PhD (Chemical Engineering) degrees




© Brunel University 2010